Initiative D21 conducts comprehensive empirical research and publishes flagship studies such as the D21-Digital-Index and eGovernment MONITOR. These publications deliver evidence-based data on digital literacy, society, and e-government adoption to help leaders in government, business, and academia make informed policy and strategic decisions.

Initiative D21 operates neutral working groups and multi-stakeholder initiatives focusing on digital education, innovative state administration, physical AI, and digital ethics. These collaborative forums bring together experts across public sector, private enterprise, and civil society to analyze technological trends, formulate digital policy recommendations, and establish practical guidelines for societal digital transformation.

Initiative D21 organizes high-level network events, specialist congresses, and discussion formats such as GovTalk, D21talk, and Lunch & Learn sessions. These events provide a collaborative platform for leaders from politics, public administration, industry, and academia to debate pressing issues regarding digital governance, cybersecurity, and societal resilience.